Open Call for Cover Art – Crowe Lab

Submit Art Here: https://goo.gl/forms/wmXbqSFADTrF5hnr1

Please email if you have any questions: Kendra.h.oliver@Vanderbilt.edu

Cover Artwork

Authors are encouraged to submit artwork for consideration. Cover images are normally (but not necessarily) linked to specific papers in that issue, but we may also be able to use other images elsewhere in the journal. Illustrations are selected for their scientific interest and aesthetic appeal.

 

ABSTRACT:

The human genome contains approximately 20 thousand protein-coding genes1, but the size of the collection of antigen receptors of the adaptive immune system that is generated by the recombination of gene segments with non-templated junctional additions (on B cells) is unknown—though it is certainly larger by one or more orders of magnitude. It has not been established whether individuals possess unique (or private) repertoires or substantial components of shared (or public) repertoires. Here we sequence recombined and expressed B cell receptor genes in several individuals to determine the size of their B cell receptor repertoires, and the extent to which these are shared between individuals. Our experiments revealed that the circulating repertoire of each individual contained between 9 and 17 million B cell clonotypes. The three individuals we studied shared many clonotypes, including between 1 and 6% of B cell heavy-chain clonotypes shared between two subjects (0.3% of clonotypes shared by all three) and 20 to 34% of l or k light chains shared between two subjects (16 or 22% of l or k light chains, respectively, shared by all three). Some of the B cell clonotypes had thousands of clones, or somatic variants, within the clonotype lineage. Although some of these shared lineages might be driven by exposure to common antigens, previous exposure to foreign antigens was not the only force that shaped the shared repertoires, as we also identified shared clonotypes in cord-blood samples and all adult repertoires. The unexpectedly high prevalence of shared clonotypes in B cell repertoires, and identification of the sequences of these shared clonotypes, should enable better understanding of the role of B cell immune repertoires in health and disease.

Chem Nature article on cover art: http://blogs.nature.com/nautilus/2010/02/making_your_mark_on_the_journa.html

1 Comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s